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參數(shù)資料
| 型號(hào)： | SC-8986 |
| 廠商： | Santa Cruz Biotechnology, Inc. |
| 英文描述： | SX Series Subminiature Basic Switch, Single Pole Double Throw (SPDT), 250 Vac, 4 A, Pin Plunger Actuator, Solder Termination |
| 中文描述： | 核因子- 1（高- 205） |
| 文件頁(yè)數(shù)： | 1/1頁(yè) |
| 文件大?。?/td> | 46K |
| 代理商： | SC-8986 |
U.S. 1.800.457.3801 831.457.3800 fax 831.457.3801 Europe +800 4573 8000 49 (0)6221 4503 0 fax 49 (0)6221 4503 45 www.scbt.com
April 2000
2002 Santa Cruz Biotechnology, Inc. All Rights Reserved.
Santa Cruz Biotechnology, Inc.
SANTA CRUZ
B I O T E C H N O L O G Y
HNF-1 (H-205):
sc-8986
BACKGROUND
HNF-1 (
α
and
β
), HNF-3 (
α
,
β
and
γ
), HNF-4 (
α
and
γ
), and
HNF-6 compose, in part, a homoeprotein family designated the
Hepatocyte Nuclear Factor family (1-4). The various HNF-1
isoforms regulate transcription of genes in the liver as well as in
other tissues such as kidney, small intestine and thymus (1).
HNF-3
α
, HNF-3
β
and HNF-3
γ
regulate the transcription of
numerous hepatocyte genes in adult liver. HNF-3
α
and HNF-3
β
have also been shown to be involved in gastrulation events such as
body axis formation (2,4). HNF-4
α
and HNF-4
γ
have been
shown to be important for early embryo development. HNF-4a is
expressed in liver, kidney, pancreas, small intestine, testis and
colon; and HNF-4
γ
is expressed in each of these tissues except
liver (3). HNF-6 has been shown to bind to the promoter of
HNF-3
β
, which indicates a potential role of HNF-6 in gut
endoderm epithelial cell differentiation. Evidence suggests that
HNF-6 may also be a transriptional activator for at least 22 other
hepatocyte-enriched genes, including cytochrome P450 2C13 and
α
-1 antitrypsin (4).
SOURCE
HNF-1 (H-205) is a rabbit polyclonal antibody raised against a
recombinant protein corresponding to amino acids 80-284
mapping within an internal region of HNF-1
α
of human origin.
PRODUCT
Each vial contains 200 μg IgG in 1.0 ml of PBS containing
0.1% sodium azide and 0.2% gelatin.
Also available as HNF-1 (H-205) X TransCruz antibody:
sc-8986 X for gel supershift studies; supplied as 200 μg IgG in
0.1 ml PBS containing 0.1% sodium azide.
STORAGE
Store at 4° C, do not freeze; stable for one year from the date of
shipment.
SPECIFICITY
HNF-1 (H-205) reacts with HNF-1
α
and HNF-1
β
of mouse, rat
and human origin by Western blotting, immunoprecipitation and
immunohistochemistry (including paraffin-embedded sections).
HNF-1 (H-205) X TransCruz antibody is recommended for gel
supershift studies.
Recommended dilution range for Western blot analysis:
1:200–1:1000. Recommended starting dilution: 1:200.
Molecular weight of HNF-1: 75 kDa, 67 kDa.
Western blotting positive control: Hep G2 WCL, sc-2227: mouse
liver extract, sc-2256; rat liver extract, sc-2395.
RESEARCH USE
For research use only, not for use in diagnostic procedures.
REFERENCES
1. Bach, I. and Yaniv, M. 1993. More potent transcriptional
activators or a transdominant inhibitor of the HNF1
homeoprotein family are generated by alternative RNA processing.
EMBO J. 12: 4229-4242.
2. Kaestner, K.H., Hiemisch, H., Luckow, B., and Schutz, G.
1994. The HNF-3 gene family of transcription factors in
mice:gene structure, cDNA sequence, and mRNA distribution.
Genomics 20: 377-385.
3. Drewes, T., Senkel, S., Holewa, B., and Ryffel, G.U. 1996.
Human hepatocyte nuclear factor 4 isoforms are encoded by
distinct and differentially expressed genes. Mol. Cell Biol.
16: 925-931.
4. Samadani, U. and Costa, R.H. 1996. The transcriptional
activator hepatocyte nuclear factor 6 regulates liver gene expression.
Mol. Cell Biol. 16: 6273-6284.
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